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Christopher Bettinger. Stephen Kustra. Haosheng Wu. Download PDF. A short summary of this paper. Lithography-free fabrication of reconfigurable substrate topography for contact guidance. Here we present a lithography-free fabrication technique that can reversibly present Contact guidance Microfabrication topographical cues using an actuation mechanism that minimizes the confounding effects of applied Microstructure stimuli. This method utilizes strain-induced buckling instabilities in bilayer substrate materials with rigid uniform silicon oxide membranes that are thermally deposited on elastomeric substrates.

Taken together, substrates that present topographic structures reversibly can elucidate dynamic aspects of celletopography interactions. All rights reserved. Introduction cellematerials interactions such as contact guidance. However, there is a limit to the insight that can be gained by interrogating Mammalian cells can detect the topography of biomaterials in dynamic systems with static cues. Substrates that present topog- both natural and synthetic microenvironments [1e5].

Topography raphy with spatiotemporal control are advantageous in studying plays an important role in determining the collective cell behavior cellematerials interactions including contact guidance. They can in many complex biological processes in development, wound potentially decouple contact guidance responses from other con- healing, and tissue regeneration [1,4,6e11]. Topographical cues founding processes such as cell attachment and spreading [5,26].

Most phenomeno- through recent advances in stimuli-responsive materials [27,28] logical studies that correlate cell function with feature geometry precise delivery of stimuli such as temperature changes, light, or and size employ substrates with static structures [7,17e25]. Static mechanical strain [1,4,10,16,20,28,29]. This strategy has been used surfaces can extract many complex mechanisms that underpin for dynamic microstructure presentation to study cellematerials interactions in numerous contexts [1,3,5,30].

E-mail address: cjbetti gmail. Pholpabu et al. Statistical methods bolism, viability, or proliferation of cell populations [33]. For Cell morphodynamic measurements were based on at least cells per each example, changes in temperature, the presence of enzymes, or data point and all experiments were repeated in triplicate. All data is shown as irradiated light can impact basal cell function [3,33].

A Student's t-test with p-value of 0. One-way ANOVA with Tukey post-hoc criterion was graphic feature formation because it is rapid, robust, and facile [1,5]. Results and discussion Mammalian cells can detect strains of the underlying substrate as small as 3.

Microstructural characterization of dynamic topography morphology [35,36]. Strain-induced topography rapid programmable presentation of topographic cues. Ordered will ideally utilize mechanical stimuli that are below the lower limit buckling is an energy-relief mechanism that occurs when a thin of detection for mammalian cells. Furthermore, mechanical stimuli rigid membrane on an elastomeric substrate is compressed can be coupled with materials that can reversibly present homo- [39,40].

Releasing the pre-strain of bilayer substrates produces geneous topographical cues in various orientations. Herein we grating arrays composed of ridge-groove features with short-range report a lithography-free fabrication technique that is capable of order Fig.

This phenomenon has been used as a non- producing strain-induced topography using sub-threshold uniaxial conventional microfabrication technique [42]. Rigid silicon oxide strains. One 2. Pre-strained substrates were within the substrate. The alternative method described herein coated with nm of silicon oxide SiOx deposited by thermal evaporation.

All substrates were pro- cessed in an identical manner with the exception that the thickness of the bilayer This approach reduces the effective critical strain required for membrane was set at either 10 or nm. Dynamic topography sequences were feature formation via compression. Although the exact composi- switched between states in less than 3 s. Microstructures of bilayer membranes tion of SiOx rigid membranes depends upon the deposition pro- were characterized using optical microscopy Olympus BH2 microscope, Olympus cedure, the composition will hereby be referred to as SiO2 for America Inc.

Cycling the strain forms microstructures reversibly as indicated by optical and scanning probe microscopy. This feature height is an order of unless otherwise stated. Live cell images were performed by culturing cells for 24 h prior to dynamic topography sequences. FB were imaged in phase contrast and grating arrays with net compressive strains can be predicted using analyzed using NIH ImageJ to measure morphology and relative orientation.

Cell the following relationships: circularity was calculated using the following expression. Feature formation the amount of pre-strain. Parallel features no short-range order and an Rms roughness of 0. Strain-dependent topography can be cycled without any 4. The intensity and orientation of these data membrane or mechanical failure of the PDMS substrate. The feature membranes offer additional advantages for use in dynamic Fig. The direction of the grating is indicated by the red arrows.

Actin and nuclei are shown in green and blue, respectively. The precise selection of the SiO2 membrane permits substrates These results suggest that static surfaces with grating topography substrates in terms of surface chemistry and applied topography can recapitulate the highly conserved morphological strain.

These measurements generate a baseline to compare the evolution of FB cytoskeleton morphology 3. Four parameters graphical features through cytoskeleton reorganization [26]. The were used to quantify FB morphology: circularity Ccell, ratio of strain detection threshold for mammalian cells in response to Fig. The rapid switching of substrate topographies does not induce observable morphological changes in FB over the span of 30 s.

This threshold provides a bench- morphodynamics. FB impact other as of yet unknown aspects of cellematerials in- morphology was largely preserved immediately after applied teractions. The orthogonal and parallel axes refer to utilized to assess the potential impact of strains in the sub- the relative orientation of the grating features to the direction of threshold regime. Static substrates that are either Flat F or Wavy applied strain.

The viously reported detection limit for contact guidance [55]. Maintaining constant material properties in dynamic substrates can be challenging [5]. Single cell sensing on programmable substrates achieve dynamic programmable topography while preserving many of the other physicochemical aspects of the cellular Programmable substrates can measure the cytoskeleton microenvironment.

This observa- cytoskeleton dynamics that are substantially different compared to tion is curious because the minimum apparent strain detection Static F substrates. Furthermore, the the following parameters that are associated with elongated mor- strains applied in this system are approximately 1 order of phologies: circularity Ccell, projected area Aproj, and axial ratio Raxis. It is unlikely that the application of transient strains Temporary presentation of topographical cues may engage mem- will directly impact binding between integrins and adhesion- ory mechanisms in mammalian cells that have been previously promoting peptides because of the strength of these bonds [60].

FB cultured on substrates with coupling. Transient Fig. Morphodynamics of a single FB in response to substrate perturbations. Single cells are captured before and after topographical switching, indicated at zero time point Phase contrast micrographs are processed using NIH ImageJ to depict changes of cellular shape and orientation. Nano- topography-guided tissue engineering and regenerative medicine.

Adv Drug teins that induce an altered state in which the cell rapidly in- Deliv Rev ;e This topic is Accelerated endothelial wound healing on microstructured substrates under the subject of ongoing research. Biomaterials ;e Conclusions Godin M, et al. Three dimensional spatial separation of cells in response to microtopography. The motility of normal and cancer cells in response to the combined during contact guidance.

Control of decouples potential contributions from other stimuli including proliferation and osteogenic differentiation of human dental-pulp-derived substrate chemistry and large mechanical strains. Homogeneous stem cells by distinct surface structures. Acta Biomater ;e Unidirectional migration of single are key features of the approach described herein. Although the smooth muscle cells under the synergetic effects of gradient swelling cue and substrate cannot completely eliminate the effect of external me- parallel groove patterns.

Colloids Surf B Biointerfaces ;C:1e6. Shape-dependent cell migration and focal small strains minimizes the impact of the applied stimulus. Acta work represents a strategy to better isolate the effect of dynamic Biomater ;e The switching of focal programmable topography on living cells.

Yale University. Polymer Science Materials Chemistry. Journal of the American Chemical Society 36 , , Journal of the American Chemical Society 11 , , Angewandte Chemie International Edition 53 15 , , Light-controlled radical polymerization: mechanisms, methods, and applications M Chen, M Zhong, JA Johnson Chemical reviews 17 , , Reversible-deactivation radical polymerization in the presence of metallic copper. Macromolecules 46 22 , , Polymer Chemistry 5 15 , , Macromolecules 47 2 , , Nature chemistry 8 1 , 33 , How fast can a CRP be conducted with preserved chain end functionality?

M Zhong, K Matyjaszewski Macromolecules 44 8 , , Macromolecules 45 1 , ,

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When the precisely timed battery charge runs out, the film dissolves and the medicine is released. Chris Bettinger discussed with the Pittsburgh Post-Gazette his research on micro-electronics that can attach to soft tissues in the human body and that have medical applications. Materials science researchers at Carnegie Mellon develop new materials and processes to fabricate neural probes that mimic the mechanical properties of the nervous system.

The research was featured on Science Friday. Search Search. Office Wean Hall Phone Behind the Researcher. Edible Electronics. Integrating Medical Devices into the Human Body. Education Ph. In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems.

Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included. Biomaterials Forum Reporter: Scott A. Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy immune-modulation , cell and gene therapy, immune microenvironment engineering, and systems immunology.

These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas.

Vice Chair: Susan N. Program Dept. Riverside, CA t: e: acipr ucr. The scope of the Ophthalmology Special Interest Group encompasses both the development and biocompatibility testing of materials for the augmentation and replacement of diseased ocular tissues and the development and testing of drug delivery systems to the anterior and posterior segments of the eye. Some specific areas of interest include but are not limited to: wetting of surfaces; surface modification and protein adsorption of polymers used for refractive devices; transport through polymers, drug delivery systems and technologies; vitreous replacement fluids; retinal tamponades, and glaucoma drainage devices for the regulation of intraocular pressure.

Program Chair: Yasushi P. Pleasanton, CA t: e: vbluetran gmail. Pittsburgh, PA t: x f: e: mod8 pitt. The Orthopaedic Biomaterials Special Interest Group is focusing on new technologies and materials advances in orthopaedic surgery. The three immediate goals of this emerging Special Interest Group are: 1 solicitation of new members for the Special Interest Group from current Society membership and from non-members actively engaged in research and development of improved materials for orthopaedics, 2 identification of key issues in orthopaedic materials that should be addressed within the Society, and 3 cooperation between Special Interest Group membership and the chairman of the Program Committee for the Annual Meeting to assist in the coordination of the scientific program.

Web Contact: Chandra M. The Proteins and Cells at Interfaces Special Interest Group seeks to promote a better understanding of cell and protein interactions with biomaterial interfaces. To achieve these goals, the group organizes activities related to the evaluation of existing materials and the design of new materials to produce targeted responses by proteins and cells. Some of the topics related to proteins include: 1 relating surface chemistry to protein adsorption or specific binding and 2 studying the activation or inactivation of protein function at interfaces, including complement activation.

Cell topics include: 1 the response of cells to differing chemistries and microstructures roughness or porosity , 2 the evaluation of multiple cell and tissue response parameters attachment, growth, migration, differentiation, inflammation, fibrosis , 3 the role of surface receptors in cell responses, and 4 all relevant cell types including bacteria. The group organizes workshops, symposia, and sessions at the Annual Meeting. Chair: Nathan D. Gallant, Ph. Vice-Chair: Pranav Soman, Ph.

Capadona, PhD L. Science Forbes Ave. Past Chair: Carl G. Simon, Jr. ND Cleveland, OH t: e: bsivaraman gmail. The Surface Characterization and Modification Special Interest Group emphasizes two major research topics: 1 improving understanding of biomaterial surface structure and its relationship to biological performance, and 2 developing surface modification strategies for biomaterials. This Special Interest Group will be active in arranging workshops, symposia, and Annual Meeting sessions for the Society.

Through these venues the Special Interest Group will provide a forum for exchange of ideas, methods, and expertise in surface characterization and modification. Career Ave. Mani usd. Past Chair: Lawrence Salvati, Jr. Rochester, NY t: e: lawrence. Apt 2 Sioux Falls, SD t: e: sjnlamichhane gmail.

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Adam P. Willard Massachusetts Institute of Technology mit. Robert G. Yale University. Polymer Science Materials Chemistry. Journal of the American Chemical Society 36 , , Journal of the American Chemical Society 11 , , Angewandte Chemie International Edition 53 15 , , Light-controlled radical polymerization: mechanisms, methods, and applications M Chen, M Zhong, JA Johnson Chemical reviews 17 , , Reversible-deactivation radical polymerization in the presence of metallic copper.

Macromolecules 46 22 , , Polymer Chemistry 5 15 , , Macromolecules 47 2 , , Nature chemistry 8 1 , 33 , Evidence before this study. The Global Burden of Diseases, Injuries, and Risk Factors Study GBD produces the only assessment of prevalence, incidence, and years lived with disability YLDs for a comprehensive list of diseases and injuries, and for all countries from to the present.

Chair Anne Kahru 1,2, anne. Infections and infectious diseases are considered a major challenge Beatriu Escuder Unversitat Jaume 1, Spain. Dan Heller Memorial Sloan So immense, in fact, that at the beginning of the show and of each subsequent season they have to put subtitles bearing their names for each of their on camera appearances! Welfare fraud Wikipedia Welfare fraud is the act of illegally using state welfare systems by knowingly withholding or giving information to obtain more funds than would otherwise be allocated..

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Global, regional, and national life expectancy, all cause Global, regional, and national life expectancy, all cause mortality, and cause specific mortality for causes of death, — a systematic analysis for the Global Burden of Disease Study 20th International Congress on In Vitro Toxicology Mathias Cormann was born in the German speaking part of Belgium and decided to migrate to Australia permanently, after first visiting Perth in , attracted by the great lifestyle and opportunities on offer in Western Australia.

The Bunderssieger Zuchtschau is held every year in Germany. How to generate free unmetered self sustaining electrical According to research done by the University College London and by Dr. Robert H. Lustig, M. The therapeutic use of ionophores in veterinary medicine has grown in the last years, with resultant increase in the risk of poisoning in animals. It provides an international forum for the publication of original research reports and authoritative review articles on biomedical glasses and their use in clinical applications.

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This thesis details fundamental investigations into the deposition, oxidation, and adhesive mechanisms of PDA films. Depositing PDA films on substrates with different controlled chemistries revealed the importance of solution pH and initial deposition rates on the morphology of the films. The deposition of PDA molecules with increasing pH depends on two competing factors: increased generation rate of PDA molecules versus increased solubility due to catechol ionization. The areal density and coverage of three-dimensional PDA islands is influenced by the surface charge and hydrophobicity of the substrate in aqueous solutions.

Spectroscopic and electrochemical characterization of PDA films revealed that redox-inactive metal cations can accelerate the oxidation of PDA. The generation of radicals of 5,6-dihydroxyindole were monitored in situ via ultraviolet-visible spectroscopy as a function of cation concentration and pH. The extent of oxidation was quantified by cyclic voltammetry. The resulting oxidation modifies the metal sorption properties of PDA by generating more carboxylic acid groups and enhancing the iron chelation of the films.

PDA film adhesion is a substrate, salt, and oxidation-dependent phenomenon. Long-term adhesive stability of PDA films can be promoted by use of higher dopamine concentrations during synthesis, incorporation of multivalent cations, and avoiding alkaline conditions and strongly oxidizing electrical bias. Elastic moduli of PDA films were quantified by compressive thin film wrinkling, and the measured value of 2. This thesis helps develop a framework for understanding the synthesis, composition, microstructure, and stability of PDA films.

Some files may require a special program or browser plug-in. More Information. The supplemental file or files you are about to download were provided to ProQuest by the author as part of a dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the content, format or impact on the supplemental file s on our system.

We recommend caution as you open such files. Copyright of the original materials contained in the supplemental file is retained by the author and your access to the supplemental files is subject to the ProQuest Terms and Conditions of use. Aleksandr V. Adam P. Willard Massachusetts Institute of Technology mit. Robert G. Yale University. Polymer Science Materials Chemistry. Journal of the American Chemical Society 36 , , Journal of the American Chemical Society 11 , , Angewandte Chemie International Edition 53 15 , , Light-controlled radical polymerization: mechanisms, methods, and applications M Chen, M Zhong, JA Johnson Chemical reviews 17 , , Reversible-deactivation radical polymerization in the presence of metallic copper.

Macromolecules 46 22 , , Polymer Chemistry 5 15 , , Macromolecules 47 2 , ,

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The Biomaterials Education Special Interest Group is dedicated to the belief that all members of the biomaterials community should be provided with high quality educational opportunities in a stimulating environment. Wickenden Bldg. Past Chair: Kenneth R. Maryland Ave. Chicago, IL t: e: ghudalla uchicago. The Cardiovascular Special Interest Group has the mission to foster the professional interaction and address the common concerns of academic and industrial scientists and engineers, clinicians, and regulatory professionals concerned with the discovery, research, development, and use of biomaterials for cardiovascular devices and implants.

Bldg E Cambridge, MA t: e: lindolfi mit. Past Chair: Vipul Dave, Ph. Vice-Chair: Sarah E. Coulter Dept of Bio. Each of these approaches converge into the larger objective of restoring oral tissue structure and function.

Issues related to materials used or having potential for use intra-orally or extra-orally for the restoration, fixation, replacement, or regeneration of hard and soft tissues in and about the oral cavity and craniofacial region are included. New dental biomaterials technologies include advanced inorganic and organic materials, biomimetics, smart materials, tissue engineering, drug delivery strategies and surface modified materials.

Washington St. The Drug Delivery Special Interest Group will deal with the science and technology of controlled release of active agents from delivery systems. Controlled drug release is achieved by the use of diffusion, chemical reactions, dissolutions or osmosis, used either singly or in combination. While the vast majority of such delivery devices are based on polymers, controlled release can also be achieved by the use of mechanical pumps.

In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems. Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included. Biomaterials Forum Reporter: Scott A. Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy immune-modulation , cell and gene therapy, immune microenvironment engineering, and systems immunology.

These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas. Vice Chair: Susan N. Program Dept. Riverside, CA t: e: acipr ucr. The scope of the Ophthalmology Special Interest Group encompasses both the development and biocompatibility testing of materials for the augmentation and replacement of diseased ocular tissues and the development and testing of drug delivery systems to the anterior and posterior segments of the eye.

Some specific areas of interest include but are not limited to: wetting of surfaces; surface modification and protein adsorption of polymers used for refractive devices; transport through polymers, drug delivery systems and technologies; vitreous replacement fluids; retinal tamponades, and glaucoma drainage devices for the regulation of intraocular pressure.

Program Chair: Yasushi P. Pleasanton, CA t: e: vbluetran gmail. Pittsburgh, PA t: x f: e: mod8 pitt. The Orthopaedic Biomaterials Special Interest Group is focusing on new technologies and materials advances in orthopaedic surgery. The three immediate goals of this emerging Special Interest Group are: 1 solicitation of new members for the Special Interest Group from current Society membership and from non-members actively engaged in research and development of improved materials for orthopaedics, 2 identification of key issues in orthopaedic materials that should be addressed within the Society, and 3 cooperation between Special Interest Group membership and the chairman of the Program Committee for the Annual Meeting to assist in the coordination of the scientific program.

Web Contact: Chandra M. The Proteins and Cells at Interfaces Special Interest Group seeks to promote a better understanding of cell and protein interactions with biomaterial interfaces. To achieve these goals, the group organizes activities related to the evaluation of existing materials and the design of new materials to produce targeted responses by proteins and cells.

Some of the topics related to proteins include: 1 relating surface chemistry to protein adsorption or specific binding and 2 studying the activation or inactivation of protein function at interfaces, including complement activation.

Cell topics include: 1 the response of cells to differing chemistries and microstructures roughness or porosity , 2 the evaluation of multiple cell and tissue response parameters attachment, growth, migration, differentiation, inflammation, fibrosis , 3 the role of surface receptors in cell responses, and 4 all relevant cell types including bacteria. Our laboratory is currently focused on several specific thrusts including: BioMEMS for tissue regeneration, biodegradable electronic devices, biomimetic tissue-device interfaces, non-conventional microfabrication of biomaterials, rational biomaterials synthesis, and quantitative elucidation of biodegradation phenomena.

Christopher J. Lab Website Publications. Education Ph. Research The Laboratory for Therapeutic Biodegradable Microsystems is broadly interested in the development of biomaterials-based MEMS for use in a wide range of biomedical applications including regenerative medicine, neural interfaces, and drug delivery.

Cosmos: Artificial melanin paves way for new cosmetics and biomaterials Interfacing with the brain.